This might happen because that application is trying to use hardware acceleration to render things more quickly and smoothly. Common examples include video player applications and web browsers such as Chrome. Sometimes a mouse pointer disappears only when it moves over certain applications. If Your Pointer Only Disappears in Certain Apps It can also be that your GPU driver needs to be updated, so that it plays nicely with a newer mouse driver. Alternatively, perhaps you should roll back a new mouse driver which may be causing problems. While Windows usually does a good job of keeping things up to date, you may want to manually check that your mouse drivers are up to date. If your mouse has this feature, make sure it’s set to the correct profile for the computer you want to use it on. So you can switch between different devices at the touch of a button. Some Bluetooth mice, such as the MX Master series, support multiple device profiles. If this has not resolved your issue, refer to the following FAQ.

Under visibility, remove the check box from Display pointer trails.

Note: If your control panel is set to category view select Switch to Classic View

Remove the check from the Display pointer trails box.

Remove the check from the Enhance pointer precision box.

Remove the check box from the Display pointer trails box.

Click Mouse located under Devices and Printers.On your keyboard, hold down the Windows Key and press X.To resolve the issue, you can disable Display pointer trails and Enhance pointer precision, by following the steps below: If Display pointer trails or Enhance pointer precision is enabled in your mouse settings, it can cause visibility issues with your mouse pointer on the display attached to the USB video adapter.

Mouse cursor disappears and reappears